BIOL4397 - Evolution of Development

 Lecture 3 - Canalization

Lecture Notes [pdf]      (Note changes to sections 3.2 and 3.3)

Slides [pdf]

Required Reading

• Waddington CH (1953) Genetic assimilation of an acquired character. Evolution 7: 118-26. [pdf]

• Gibson G & Hogness DS (1996) Effect of polymorphism in the Drosophila regulatory gene Ultrabithorax on homeotic stability. Science 271: 200-203. [pdf]

Recommended Reading

• Debat V & David P (2001) Mapping phenotypes: canalization, plasticity and developmental stability. TREE 16: 555-561. [pdf]

• Gibson G & Wagner G (2000) Canalization in evolutionary genetics: a stabilizing theory? BioEssays 22: 372-380. [pdf]

• Scharloo W (1991) Canalization: genetic and developmental aspects. Ann. Rev. Ecol. Syst. 22: 65-93. [pdf]

• Slack JMW (2002) Conrad Hal Waddington: the last Renaissance biologist? Nat. Rev. Genet. 3: 889-895. [pdf]

• Waddington CH (1956) Genetic assimilation of the bithorax phenotype. Evolution 10: 1-13. [pdf]